Lifting the Differentiation Embargo

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2016 English Publisher:Elsevier BVJournal:Cell, volume 167, pages 45-46 (issn: 0092-8674,

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Authors: Latif, Anne-Louise; Holyoake, Tessa;

doi: 10.1016/j.cell.2016.08.051

pmid: 27662083

Lifting the Differentiation Embargo

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Abstract

Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.

Related Organizations

University of Glasgow
United Kingdom
Glasgow Royal Infirmary
United Kingdom
NHS Greater Glasgow and Clyde
United Kingdom

Keywords

Leukemia, Myeloid, Acute, Lifting, Humans, Cell Differentiation

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