descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2016 English Publisher:Elsevier BVJournal:Cell, volume 165, pages 248-2,480 (issn: 0092-8674,

Authors: Morreale, Francesca Ester; Walden, Helen;

doi: 10.1016/j.cell.2016.03.003

pmid: 27015313

Types of Ubiquitin Ligases

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Abstract

Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

Related Organizations

University of Dundee
United Kingdom

Keywords

Biochemistry, Genetics and Molecular Biology(all), Ubiquitin-Conjugating Enzymes, Ubiquitination, Animals, Humans, Proteins, Protein Processing, Post-Translational

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