Hedgehog Pathway Inhibition

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2016 English Publisher:Elsevier BVJournal:Cell, volume 164, page 831 (issn: 0092-8674,

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Authors: Sekulic, Aleksandar; Von Hoff, Daniel;

doi: 10.1016/j.cell.2016.02.021

pmid: 26919418

Hedgehog Pathway Inhibition

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Abstract

The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).

Related Organizations

Mayo Clinic
United States
Translational Genomics Research Institute
United States

Keywords

Skin Neoplasms, Biochemistry, Genetics and Molecular Biology(all), Pyridines, Biphenyl Compounds, Antineoplastic Agents, Smoothened Receptor, Receptors, G-Protein-Coupled, Translational Research, Biomedical, Humans, Anilides, Hedgehog Proteins, Basal Cell Carcinoma, Signal Transduction

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