
pmid: 26871623
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.
Male, Proto-Oncogene Proteins c-myc, Biochemistry, Genetics and Molecular Biology(all), Genes, myc, Animals, Female, Embryonic Stem Cells
Male, Proto-Oncogene Proteins c-myc, Biochemistry, Genetics and Molecular Biology(all), Genes, myc, Animals, Female, Embryonic Stem Cells
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