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YAP1 Takes Over when Oncogenic K-Ras Slumbers

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2014 English Publisher:Elsevier BVJournal:Cell, volume 158, pages 11-12 (issn: 0092-8674, Copyright policy )Funded by:EC | ROSCAN
Authors: Greten, Florian R.;

doi: 10.1016/j.cell.2014.06.021

pmid: 24995973

YAP1 Takes Over when Oncogenic K-Ras Slumbers

Abstract

It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.

Related Organizations
Keywords

Epithelial-Mesenchymal Transition, Lung Neoplasms, Biochemistry, Genetics and Molecular Biology(all), Cell Survival, Cell Cycle Proteins, YAP-Signaling Proteins, Adenocarcinoma, Phosphoproteins, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras), Drug Resistance, Neoplasm, Proto-Oncogene Proteins, Colonic Neoplasms, ras Proteins, Animals, Humans, Adaptor Proteins, Signal Transducing, Carcinoma, Pancreatic Ductal, Transcription Factors

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 21
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Top 10%
Average
Top 10%
hybrid
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