Galectin-1 Pulls the Strings on VEGFR2

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2014 English Publisher:Elsevier BVJournal:Cell, volume 156, pages 625-626 (issn: 0092-8674,

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Authors: Stanley, Pamela;

doi: 10.1016/j.cell.2014.01.059

pmid: 24529367

Galectin-1 Pulls the Strings on VEGFR2

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Abstract

Anti-vascular endothelial growth factor (VEGF) cancer immunotherapy targets angiogenesis but development of resistance in patients is common. In this issue of Cell, Croci et al. identify a complex set of mechanisms by which galectin-1 prolongs cell-surface retention of VEGF receptor 2 (VEGFR2) and stimulates VEGF-independent tumor angiogenesis.

Related Organizations

Albert Einstein College of Medicine
United States
Yeshiva University
United States

Keywords

Neovascularization, Pathologic, Biochemistry, Genetics and Molecular Biology(all), Vascular Endothelial Growth Factors, Neoplasms, Animals, Humans, Angiogenesis Inhibitors

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