SnapShot: Broadly Neutralizing Antibodies

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2013 English Publisher:Elsevier BVJournal:Cell, volume 155, pages 728-7,280 (issn: 0092-8674,

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Authors: Sok, Devin; Moldt, Brian; Burton, Dennis R.;

doi: 10.1016/j.cell.2013.10.009

pmid: 24243025

pmc: PMC4070420

SnapShot: Broadly Neutralizing Antibodies

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Abstract

Durably elicited by live attenuated virus, less durably by inactivated virusConserved bnAb epitopes:1) Ep1 (res. 380–400) 2) Ep2 (res. 190–200)3) Ep3 (res. 571–579)Despite the extensive variability of measles virus, nAb responses to vaccination are broad becausethe conserved epitopes are immunoprominent.May relate to overlap of the receptor-binding site and the bnAb epitopes.

Related Organizations

Scripps Research Institute
United States

Keywords

Epitopes, Biochemistry, Genetics and Molecular Biology(all), Plasmodium falciparum, Viruses, Humans, Antibodies, Neutralizing, Antigens, Viral

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