The explosion of interest in induced pluripotent stem cells has been fueled by their potential as a limitless source of cells to repair damaged tissues in any number of diseases. However, generating cells is only a small part of the problem; ensuring that these cells integrate into their new environment and function appropriately is now a more pressing challenge. In this issue's Select, we focus on four recent papers that tackle this problem and find that new ways to stimulate endogenous regeneration are providing promising alternatives to restore organ function.