EGFR in Limbo

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2012 English Publisher:Elsevier BVJournal:Cell, volume 149, pages 735-737 (issn: 0092-8674,

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Authors: Eck, Michael J.; Hahn, William C.;

doi: 10.1016/j.cell.2012.04.015

pmid: 22579278

EGFR in Limbo

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Abstract

The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.

Related Organizations

Dana-Farber Cancer Institute
United States
Broad Institute
United States
Harvard University
United States

Keywords

Biochemistry, Genetics and Molecular Biology(all)

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