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The Dangers of Transcription

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2009 English Publisher:Elsevier BVJournal:Cell, volume 139, pages 1,047-1,049 (issn: 0092-8674,

Authors: Tom Misteli; Stephan Mathas;

doi: 10.1016/j.cell.2009.11.037

pmid: 20005797

pmc: PMC6312720

The Dangers of Transcription

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Abstract

Transcription is obviously essential, but even a good thing can be dangerous at times. In this issue, Lin et al. (2009) provide evidence that binding of the transcription machinery may predispose genome regions to breakage and translocations that may lead to cancer.

Related Organizations

Helmholtz Association of German Research Centres
Germany
NATIONAL CANCER INSTITUTE
National Institutes of Health
United States
Pennsylvania State University
United States
National Institute of Health
Armenia

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Keywords

Gene Expression Regulation, Neoplastic, Biochemistry, Genetics and Molecular Biology(all), Receptors, Androgen, Humans, DNA Breaks, Double-Stranded, Translocation, Genetic

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	27
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%

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Average

Top 10%

hybrid

Fields of Science (3) View all

medical and health sciences

basic medicine

Fields of Science

medical and health sciences

basic medicine

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Related to Research communities

Cancer Research