A Ubiquitin-like Protein Unleashes Ubiquitin Ligases
Copyright policy )A Ubiquitin-like Protein Unleashes Ubiquitin Ligases
Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
- University of Mary United States
- University of Washington United States
- Howard Hughes Medical Institute United States
NEDD8 Protein, Biochemistry, Genetics and Molecular Biology(all), Ubiquitin, Humans, Ubiquitin-Protein Ligase Complexes, Crystallography, X-Ray, Cullin Proteins, Ubiquitins, Protein Structure, Tertiary
NEDD8 Protein, Biochemistry, Genetics and Molecular Biology(all), Ubiquitin, Humans, Ubiquitin-Protein Ligase Complexes, Crystallography, X-Ray, Cullin Proteins, Ubiquitins, Protein Structure, Tertiary
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