<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

A Ubiquitin-like Protein Unleashes Ubiquitin Ligases

Name: A Ubiquitin-like Protein Unleashes Ubiquitin Ligases
Keywords: NEDD8 Protein, Biochemistry, Genetics and Molecular Biology(all), Ubiquitin, Humans, Ubiquitin-Protein Ligase Complexes, Crystallography, X-Ray, Cullin Proteins, Ubiquitins, Protein Structure, Tertiary

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2008 English Publisher:Elsevier BVJournal:Cell, volume 135, pages 209-211 (issn: 0092-8674,

Authors: Ning Zheng; Ning Zheng; Nabiha Huq Saifee;

doi: 10.1016/j.cell.2008.09.049

pmid: 18957195

A Ubiquitin-like Protein Unleashes Ubiquitin Ligases

- Summary
- Subjects
- Metrics

Abstract

Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.

Related Organizations

Washington State University
United States
Howard Hughes Medical Institute
United States
University of Mary
United States

Keywords

NEDD8 Protein, Biochemistry, Genetics and Molecular Biology(all), Ubiquitin, Humans, Ubiquitin-Protein Ligase Complexes, Crystallography, X-Ray, Cullin Proteins, Ubiquitins, Protein Structure, Tertiary

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	21
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

Found an issue? Give us feedback

Top 10%

Average

hybrid