An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans
Copyright policy )An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans
To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity, indicating that elt-3, elt-5, and elt-6 play an important functional role in the aging process. These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage.
- Stanford University United States
- University of Colorado Boulder United States
- University of Colorado Health United States
- University of Colorado System United States
- Affymetrix United States
Aging, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, HUMDISEASE, RNA, Animals, Gene Expression Regulation, Developmental, CELLBIO, Gene Regulatory Networks, Caenorhabditis elegans, Caenorhabditis elegans Proteins, GATA Transcription Factors, Oligonucleotide Array Sequence Analysis
Aging, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, HUMDISEASE, RNA, Animals, Gene Expression Regulation, Developmental, CELLBIO, Gene Regulatory Networks, Caenorhabditis elegans, Caenorhabditis elegans Proteins, GATA Transcription Factors, Oligonucleotide Array Sequence Analysis
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).241 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!