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Capturing Pluripotency

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2008 English Publisher:Elsevier BVJournal:Cell, volume 132, pages 532-536 (issn: 0092-8674, Copyright policy )Funded by:WT | unidentified
Authors: Silva, Jose; Smith, Austin;

doi: 10.1016/j.cell.2008.02.006

pmid: 18295569

pmc: PMC2427053

Capturing Pluripotency

Abstract

In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.

Related Organizations
Keywords

Pluripotent Stem Cells, Biochemistry, Genetics and Molecular Biology(all), Essay, Embryo, Mammalian, Mice, Animals, Humans, Cell Lineage, Extracellular Signal-Regulated MAP Kinases, Embryonic Stem Cells, Transcription Factors

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 410
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
410
Top 1%
Top 1%
Top 0.1%
Green
hybrid