A Notch Sweeter
Copyright policy )A Notch Sweeter
Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.
- Howard Hughes Medical Institute United States
- Rutgers, The State University of New Jersey United States
Models, Molecular, Glycosylation, Receptors, Notch, Biochemistry, Genetics and Molecular Biology(all), Temperature, Genes, Insect, Catalysis, Protein Structure, Tertiary, Glucose, Gene Expression Regulation, Glucosyltransferases, Serine, Animals, Drosophila Proteins, Drosophila, Genetic Testing, Alleles, Gene Deletion, Signal Transduction
Models, Molecular, Glycosylation, Receptors, Notch, Biochemistry, Genetics and Molecular Biology(all), Temperature, Genes, Insect, Catalysis, Protein Structure, Tertiary, Glucose, Gene Expression Regulation, Glucosyltransferases, Serine, Animals, Drosophila Proteins, Drosophila, Genetic Testing, Alleles, Gene Deletion, Signal Transduction
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