Loss of T-bet Sends Host-Microbe Mutualism Awry

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2007 English Publisher:Elsevier BVJournal:Cell, volume 131, pages 15-17 (issn: 0092-8674,

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Authors: Ma, Averil;

doi: 10.1016/j.cell.2007.09.030

pmid: 17923080

Loss of T-bet Sends Host-Microbe Mutualism Awry

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Abstract

Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system.

Related Organizations

University of California, San Francisco
United States

Keywords

Homeodomain Proteins, Mice, Knockout, B-Lymphocytes, Biochemistry, Genetics and Molecular Biology(all), Tumor Necrosis Factor-alpha, T-Lymphocytes, Immunity, Innate, Intestines, Mice, Animals, Homeostasis, Humans, Colitis, Ulcerative, T-bet Transcription Factor, T-Box Domain Proteins

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