How to Assemble a Capsid

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2007 English Publisher:Elsevier BVJournal:Cell, volume 131, pages 17-19 (issn: 0092-8674,

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Authors: Sundquist, Wesley I.; Hill, Christopher P.;

doi: 10.1016/j.cell.2007.09.028

pmid: 17923081

How to Assemble a Capsid

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Abstract

Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.

Related Organizations

University of Utah
United States

Keywords

Models, Molecular, Capsid, Biochemistry, Genetics and Molecular Biology(all), HIV-1, Humans, Capsid Proteins, Protein Structure, Quaternary

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