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Genetic Screening for Signal Transduction in the Era of Network Biology

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:Elsevier BVJournal:Cell, volume 128, pages 225-231 (issn: 0092-8674, Copyright policy )
Authors: Friedman, Adam; Perrimon, Norbert;

doi: 10.1016/j.cell.2007.01.007

pmid: 17254958

Genetic Screening for Signal Transduction in the Era of Network Biology

Abstract

In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.

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Keywords

570, Biochemistry, Genetics and Molecular Biology(all), Genetic Diseases, Inborn, Computational Biology, Gene Expression Regulation, Neoplasms, 616, Animals, Humans, Gene Regulatory Networks, Genetic Testing, Molecular Biology, Signal Transduction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 140
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
140
Top 10%
Top 10%
Top 1%
hybrid