Hosting Neurotoxicity in Polyglutamine Disease
Copyright policy )Hosting Neurotoxicity in Polyglutamine Disease
Polyglutamine diseases are caused by an expanded glutamine domain thought to confer a toxic activity onto the respective disease proteins. In this issue, propose that toxicity of the polyglutamine protein Ataxin-1 may not be due to abberant protein interactions mediated by the polyglutamine expansion. Instead, they suggest that toxicity is solely due to interactions of Ataxin-1 with its normal binding partners.
- Howard Hughes Medical Institute United States
- University of Pennsylvania United States
- Department of Biology United States
- Department of Biology Switzerland
Biochemistry, Genetics and Molecular Biology(all), Models, Neurological, Nuclear Proteins, Nerve Tissue Proteins, Neurodegenerative Diseases, Repressor Proteins, Mice, Ataxins, Mutation, Animals, Humans, Spinocerebellar Ataxias, Drosophila, Peptides, Ataxin-1
Biochemistry, Genetics and Molecular Biology(all), Models, Neurological, Nuclear Proteins, Nerve Tissue Proteins, Neurodegenerative Diseases, Repressor Proteins, Mice, Ataxins, Mutation, Animals, Humans, Spinocerebellar Ataxias, Drosophila, Peptides, Ataxin-1
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!