Targeting Protein Stability with a Small Molecule
Copyright policy )Targeting Protein Stability with a Small Molecule
Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.
- Rockefeller University United States
Sirolimus, Proteasome Endopeptidase Complex, Biochemistry, Genetics and Molecular Biology(all), Recombinant Fusion Proteins, Tacrolimus Binding Protein 1A, Ligands, Protein Structure, Tertiary, Tacrolimus Binding Proteins, Luminescent Proteins, Mice, Gene Expression Regulation, Mutation, Animals, Protein Binding
Sirolimus, Proteasome Endopeptidase Complex, Biochemistry, Genetics and Molecular Biology(all), Recombinant Fusion Proteins, Tacrolimus Binding Protein 1A, Ligands, Protein Structure, Tertiary, Tacrolimus Binding Proteins, Luminescent Proteins, Mice, Gene Expression Regulation, Mutation, Animals, Protein Binding
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