FOXP3 and NFAT: Partners in Tolerance
Copyright policy )FOXP3 and NFAT: Partners in Tolerance
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.
Base Sequence, NFATC Transcription Factors, Biochemistry, Genetics and Molecular Biology(all), Molecular Sequence Data, CD24 Antigen, Autoimmunity, Forkhead Transcription Factors, Hydrogen Bonding, Crystallography, X-Ray, Lymphocyte Activation, Models, Biological, Jurkat Cells, Amino Acid Substitution, Gene Expression Regulation, Genes, Reporter, Immune Tolerance, Humans, Interleukin-2, Amino Acid Sequence, Luciferases, Biomarkers
Base Sequence, NFATC Transcription Factors, Biochemistry, Genetics and Molecular Biology(all), Molecular Sequence Data, CD24 Antigen, Autoimmunity, Forkhead Transcription Factors, Hydrogen Bonding, Crystallography, X-Ray, Lymphocyte Activation, Models, Biological, Jurkat Cells, Amino Acid Substitution, Gene Expression Regulation, Genes, Reporter, Immune Tolerance, Humans, Interleukin-2, Amino Acid Sequence, Luciferases, Biomarkers
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