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In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.
Homeodomain Proteins, Transcriptional Activation, Biochemistry, Genetics and Molecular Biology(all), Myocardium, Calcium-Binding Proteins, Cardiomegaly, Heart, Histone Deacetylases, Homeobox Protein Nkx-2.5, Trans-Activators, Animals, Humans, Myocytes, Cardiac, Signal Transduction, Transcription Factors
Homeodomain Proteins, Transcriptional Activation, Biochemistry, Genetics and Molecular Biology(all), Myocardium, Calcium-Binding Proteins, Cardiomegaly, Heart, Histone Deacetylases, Homeobox Protein Nkx-2.5, Trans-Activators, Animals, Humans, Myocytes, Cardiac, Signal Transduction, Transcription Factors
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