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Methylglyoxal Comes of AGE

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006 English Publisher:Elsevier BVJournal:Cell, volume 124, pages 258-260 (issn: 0092-8674, Copyright policy )
Authors: Ramasamy, Ravichandran; Yan, Shi Fang; Schmidt, Ann Marie;

doi: 10.1016/j.cell.2006.01.002

pmid: 16439200

Methylglyoxal Comes of AGE

Abstract

The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.

Related Organizations
Keywords

Glycation End Products, Advanced, Aging, Genome, Glycosylation, Gene Expression Regulation, Proteome, Biochemistry, Genetics and Molecular Biology(all), Animals, Humans, Pyruvaldehyde

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 149
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
149
Top 1%
Top 10%
Top 10%
hybrid