Nicastrin: Gatekeeper of the γ-Secretase Complex
Copyright policy )Nicastrin: Gatekeeper of the γ-Secretase Complex
The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex. They show that the nicastrin extracellular domain is essential for recognition of substrate by the gamma-secretase.
- Katholieke Universiteit Leuven Belgium
Membrane Glycoproteins, Biochemistry, Genetics and Molecular Biology(all), Endopeptidases, Animals, Aspartic Acid Endopeptidases, Humans, Amyloid Precursor Protein Secretases, Protein Structure, Tertiary, Signal Transduction
Membrane Glycoproteins, Biochemistry, Genetics and Molecular Biology(all), Endopeptidases, Animals, Aspartic Acid Endopeptidases, Humans, Amyloid Precursor Protein Secretases, Protein Structure, Tertiary, Signal Transduction
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