DNA Repair, Genome Stability, and Aging
Copyright policy )DNA Repair, Genome Stability, and Aging
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability, metabolism, and aging. We conclude with a general discussion of the role of mutant mice in aging research and avenues for future investigation.
- Biomedical Research Institute United States
- Harvard University United States
- Howard Hughes Medical Institute United States
DNA Repair, Biochemistry, Genetics and Molecular Biology(all), Longevity, Antigens, Nuclear, Genomic Instability, DNA-Binding Proteins, Mice, Animals, Sirtuins, Rad51 Recombinase, Tumor Suppressor Protein p53, Reactive Oxygen Species, Ku Autoantigen, Cellular Senescence, DNA Damage
DNA Repair, Biochemistry, Genetics and Molecular Biology(all), Longevity, Antigens, Nuclear, Genomic Instability, DNA-Binding Proteins, Mice, Animals, Sirtuins, Rad51 Recombinase, Tumor Suppressor Protein p53, Reactive Oxygen Species, Ku Autoantigen, Cellular Senescence, DNA Damage
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