Calcium in the Golgi apparatus

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2007 English Publisher:Elsevier BVJournal:Cell Calcium, volume 41, pages 405-416 (issn: 0143-4160,

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Authors: Ludwig, Missiaen; Leonard, Dode; Jo, Vanoevelen; Luc, Raeymaekers; Frank, Wuytack;

doi: 10.1016/j.ceca.2006.11.001

pmid: 17140658

Calcium in the Golgi apparatus

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Abstract

The secretory-pathway Ca2+-ATPases (SPCAs) represent a recently recognized family of phosphorylation-type ATPases that supply the lumen of the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this structure. Mutations of the human SPCA1 gene (ATP2C1) cause Hailey-Hailey disease, an autosomal dominant skin disorder in which keratinocytes in the suprabasal layer of the epidermis detach. We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder.

Related Organizations

Katholieke Universiteit Leuven
Belgium

Keywords

Pemphigus, Benign Familial, Animals, Golgi Apparatus, Humans, Calcium, Calcium-Transporting ATPases

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