Drugs, hERG and sudden death
Copyright policy )Drugs, hERG and sudden death
Early recognition of potential QT/TdP liability is now an essential component of the drug discovery/drug development program. The hERG assay is an indispensable step and a high-quality assay must accompany any investigational new drug (IND) application. While it is the gold standard at present, the hERG assay is too labor-intensive and too low throughput to be used as a screen early in the discovery/development process. A variety of indirect high throughput screens have been used.
- Case Western Reserve University United States
ERG1 Potassium Channel, Long QT Syndrome, Death, Sudden, Cardiac, Potassium Channels, Potassium Channels, Voltage-Gated, Drug Evaluation, Preclinical, Humans, Terfenadine, Ether-A-Go-Go Potassium Channels
ERG1 Potassium Channel, Long QT Syndrome, Death, Sudden, Cardiac, Potassium Channels, Potassium Channels, Voltage-Gated, Drug Evaluation, Preclinical, Humans, Terfenadine, Ether-A-Go-Go Potassium Channels
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