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Current Opinion in Cell Biology
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Article . 2011
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mTOR signaling in disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2011 Switzerland English Publisher:Elsevier BVJournal:Current Opinion in Cell Biology, volume 23, pages 744-755 (issn: 0955-0674, Copyright policy )Funded by:SNSF | Mass Spectrometry in Biol..., SNSF | TOR signaling and control...
Authors: Dazert, E.; Hall, M. N.;

doi: 10.1016/j.ceb.2011.09.003

pmid: 21963299

mTOR signaling in disease

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.

Country
Switzerland
Related Organizations
Keywords

Mammals, Disease Models, Animal, Neoplasms, TOR Serine-Threonine Kinases, Animals, Humans, Cell Proliferation, Signal Transduction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 426
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
426
Top 1%
Top 1%
Top 0.1%
Related to Research communities
Cancer Research