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Current Opinion in Cell Biology
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Current Opinion in Cell Biology
Article . 2010 . Peer-reviewed
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Nucleolar dominance and ribosomal RNA gene silencing

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2010 English Publisher:Elsevier BVJournal:Current Opinion in Cell Biology, volume 22, pages 351-356 (issn: 0955-0674, Copyright policy )
Authors: Sarah, Tucker; Alexa, Vitins; Craig S, Pikaard;

doi: 10.1016/j.ceb.2010.03.009

pmid: 20392622

pmc: PMC2912983

Nucleolar dominance and ribosomal RNA gene silencing

Abstract

Nucleolar dominance is an epigenetic phenomenon that occurs in genetic hybrids and describes the expression of 45S rRNA genes inherited from one progenitor due to the silencing of the other progenitor's rRNA genes. Nucleolar dominance is a manifestation of rRNA gene dosage control, which also occurs in non-hybrids, regulating the number of active rRNA genes according to the cellular demand for ribosomes and protein synthesis. Ribosomal RNA gene silencing involves changes in DNA methylation and histone modifications, but the molecular basis for choosing which genes to silence remains unclear. Recent studies indicate a role for short interfering RNAs (siRNAs) or structured regulatory RNAs in rRNA gene silencing in plants or mammals, respectively, suggesting that RNA may impart specificity to the choice mechanism.

Related Organizations
Keywords

RNA, Ribosomal, Gene Dosage, Animals, Humans, Genes, rRNA, Gene Silencing, Plants, Cell Nucleolus, Chromatin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
98
Top 10%
Top 10%
Top 10%
bronze
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