Mitotic chromosome structure and condensation

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2006 English Publisher:Elsevier BVJournal:Current Opinion in Cell Biology, volume 18, pages 632-638 (issn: 0955-0674,

Copyright policy )

Authors: Andrew S, Belmont;

doi: 10.1016/j.ceb.2006.09.007

pmid: 17046228

Mitotic chromosome structure and condensation

- Summary
- Subjects
- Metrics

Abstract

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

Related Organizations

University of Illinois System
United States
University of Illinois at Urbana–Champaign
United States

Keywords

Adenosine Triphosphatases, Mitosis, Models, Biological, Chromatin, Chromosomes, DNA-Binding Proteins, Histones, DNA Topoisomerases, Type II, Chromosome Segregation, Multiprotein Complexes, Animals, Humans

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	170
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%