Biophosphonate-Related Osteonecrosis of the Jaws

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 English Publisher:Elsevier BVJournal:Dental Clinics of North America, volume 52, pages 111-128 (issn: 0011-8532,

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Authors: Salvatore L, Ruggiero; Sook-Bin, Woo;

doi: 10.1016/j.cden.2007.09.002

pmid: 18154867

Biophosphonate-Related Osteonecrosis of the Jaws

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Abstract

In 2003 and 2004, the first reports of patients who developed necrosis of the jawbones while taking biophosphonates appeared in literature; most patients were on this drug for treatment of cancer and some osteoporosis. Since then, more than 500 cases have been identified and the number of these cases continues to grow. This article reviews the action of bisphosphonates, the condition called bisphosphonate-associated osteonecrosis of the jaws, strategies to minimize occurrence, and treatment of this condition.

Related Organizations

Stony Brook University
United States
Harvard University
United States
Brigham and Women's Faulkner Hospital
United States

Keywords

Radiography, Bone Density Conservation Agents, Diphosphonates, Risk Factors, Osteonecrosis, Humans, Jaw Diseases

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