This article presents a review of materials currently used in the practice of endodontics. Current endodontic materials include those that have been thoroughly tested by scientific investigation, clinical usage, and time, as well as others that are the result of new knowledge in the field of dental materials. Article sections are devoted to obturation materials, sealers, irrigation materials, smear layer removal, root-end filling materials, and intracanal medicaments. Knowing the particular qualities of materials can aid the clinician in choosing those that are appropriate for a given situation. Properties, components, and rationale for the materials' use are presented to aid the clinician in choosing materials for a particular need.