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Endoplasmic Reticulum Stress in Malignancy

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2014Embargo end date: 30 Jan 2020 United Kingdom English Publisher:Elsevier BVJournal:Cancer Cell, volume 25, pages 563-573 (issn: 1535-6108,

Authors: Clarke, Hanna J; Chambers, Joseph E; Liniker, Elizabeth; Marciniak, Stefan J;

doi: 10.1016/j.ccr.2014.03.015 , 10.17863/cam.23187

pmid: 24823636

Endoplasmic Reticulum Stress in Malignancy

- Summary
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Abstract

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

Country

United Kingdom

Related Organizations

Wellcome Trust
United Kingdom
University of Cambridge
United Kingdom

Keywords

Cancer Research, Protein Folding, Neovascularization, Pathologic, Cell Survival, Antineoplastic Agents, Cell Biology, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Boronic Acids, Activating Transcription Factor 6, Bortezomib, eIF-2 Kinase, Oncology, Neoplasms, Pyrazines, Endoribonucleases, Unfolded Protein Response, Humans, Cell Proliferation

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	411
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%