Percutaneous coronary intervention has evolved dramatically over the past 25 years as coronary stents replaced stand-alone balloon angioplasty. Improvements in stents were made in the 1990s, but a breakthrough occurred in early 2000 with the development of stents that eluted pharmacology agents directly into the vessel wall by means of a controlled release from a durable polymer coating. Various drug-eluting stents were developed,each varying with its delivery platform, polymer coating (or absence of coating),and drug selected for elution. This article describes the clinically available and late developmental drug-eluting stent programs targeted for treating patients who have coronary artery disease.