Pulling a MAST1 on Cisplatin Resistance

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2018 English Publisher:Elsevier BVJournal:Cancer Cell, volume 34, pages 183-185 (issn: 1535-6108,

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Authors: Ankita B, Jaykumar; Aroon S, Karra; Melanie H, Cobb;

doi: 10.1016/j.ccell.2018.07.010

pmid: 30107173

Pulling a MAST1 on Cisplatin Resistance

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Abstract

In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.

Related Organizations

The University of Texas Southwestern Medical Center
United States

Keywords

Drug Resistance, Neoplasm, MAP Kinase Signaling System, Humans, Antineoplastic Agents, Cisplatin, Protein Serine-Threonine Kinases

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