Targeting mRNA Decapping in AML

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018 English Publisher:Elsevier BVJournal:Cancer Cell, volume 33, pages 339-341 (issn: 1535-6108,

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Authors: Akihide, Yoshimi; Omar, Abdel-Wahab;

doi: 10.1016/j.ccell.2018.02.015

pmid: 29533777

pmc: PMC6614869

Targeting mRNA Decapping in AML

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Abstract

In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3'-to-5' mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

Keywords

Leukemia, Myeloid, Acute, Endoribonucleases, Humans, RNA, Messenger

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