Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2017 English Publisher:Elsevier BVJournal:Cancer Cell, volume 31, pages 729-731 (issn: 1535-6108,

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Authors: Michael J, Thirman;

doi: 10.1016/j.ccell.2017.05.014

pmid: 28609652

pmc: PMC5783294

Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia

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Abstract

Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemia. In this issue of Cancer Cell, Chen et al. describe complementary approaches demonstrating that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis. They also observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential therapeutic targets.

Related Organizations

University of Chicago
United States
THE UNIVERSITY OF CHICAGO
United States

Keywords

Leukemia, Humans, Histone-Lysine N-Methyltransferase, Myeloid-Lymphoid Leukemia Protein

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