Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2017 English Publisher:Elsevier BVJournal:Cancer Cell, volume 31, pages 474-475 (issn: 1535-6108,

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Authors: Deobrat, Dixit; Qi, Xie; Jeremy N, Rich; Jing Crystal, Zhao;

doi: 10.1016/j.ccell.2017.03.010

pmid: 28399407

pmc: PMC6482444

Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis

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Abstract

Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

Related Organizations

Cleveland Clinic
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Discovery Institute
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Cleveland Clinic Lerner Research Institute
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Sanford Burnham Prebys Medical Discovery Institute
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Keywords

Cell Transformation, Neoplastic, Carcinogenesis, Humans, RNA, Messenger, Glioblastoma, Methylation

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