One Step Forward in the Challenging Arena of MLL-AF4 Leukemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2016 English Publisher:Elsevier BVJournal:Cancer Cell, volume 30, pages 657-658 (issn: 1535-6108,

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Authors: Nancy J, Zeleznik-Le;

doi: 10.1016/j.ccell.2016.10.017

pmid: 27846384

One Step Forward in the Challenging Arena of MLL-AF4 Leukemia

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Abstract

MLL-AF4 leukemia is the predominant infant acute leukemia and has a poor prognosis. No current experimental models accurately reflect the human disease. Lin et al., in this issue of Cancer Cell, describe their model that recapitulates multiple key aspects of this aggressive disease, facilitating future mechanistic and preclinical studies.

Related Organizations

Loyola University Chicago
United States

Keywords

Leukemia, Oncogene Proteins, Fusion, Humans, Myeloid-Lymphoid Leukemia Protein

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