Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2016 English Publisher:Elsevier BVJournal:Cancer Cell, volume 30, pages 371-373 (issn: 1535-6108,

Copyright policy )Funded by:NIH | Role of ASXL1 mutations i...

Authors: Daichi, Inoue; Omar, Abdel-Wahab;

doi: 10.1016/j.ccell.2016.08.013

pmid: 27622329

pmc: PMC5569387

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities

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Abstract

In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

Keywords

RNA Splicing, Mutation, Spliceosomes, Animals, RNA Splicing Factors, Phosphoproteins

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