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Cancer Cell
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Cancer Cell
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License: Elsevier Non-Commercial
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Sticking It to Cancer with Molecular Glue for SHP2

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 English Publisher:Elsevier BVJournal:Cancer Cell, volume 30, pages 194-196 (issn: 1535-6108, Copyright policy )
Authors: Hao, Ran; Ryouhei, Tsutsumi; Toshiyuki, Araki; Benjamin G, Neel;

doi: 10.1016/j.ccell.2016.07.010

pmid: 27505669

pmc: PMC5558882

Sticking It to Cancer with Molecular Glue for SHP2

Abstract

Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.

Related Organizations
Keywords

Mice, Neoplasms, Animals, Humans, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Molecular Targeted Therapy, Protein Kinase Inhibitors

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 91
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
91
Top 1%
Top 10%
Top 10%
hybrid
Related to Research communities
Cancer Research