Bringing IDH into the Fold

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2016 English Publisher:Elsevier BVJournal:Cancer Cell, volume 29, pages 139-140 (issn: 1535-6108,

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Authors: Zadeh, Gelareh; Aldape, Kenneth;

doi: 10.1016/j.ccell.2016.01.010

pmid: 26859452

Bringing IDH into the Fold

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Abstract

Glioma-associated mutations in IDH1 or IDH2 lead to aberrant DNA methylation. A recent paper shows that loss of methylation-sensitive CTCF binding in IDH mutant cells leads to disruption of enhancer boundary function, which results in aberrant activation of PDGFRA expression via an enhancer associated with an adjacent gene.

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Keywords

Gene Expression Regulation, Neoplastic, Cancer Research, Oncology, Mutation, Humans, Insulator Elements, Cell Biology, Glioma, Oncogenes, Isocitrate Dehydrogenase

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