
pmid: 25873170
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.
Cancer Research, T-Lymphocytes, Cell Biology, Cell Cycle Checkpoints, B7-H1 Antigen, 1307 Cell Biology, Oncology, Animals, Humans, 1306 Cancer Research, 2730 Oncology, CTLA-4 Antigen, Female, Melanoma
Cancer Research, T-Lymphocytes, Cell Biology, Cell Cycle Checkpoints, B7-H1 Antigen, 1307 Cell Biology, Oncology, Animals, Humans, 1306 Cancer Research, 2730 Oncology, CTLA-4 Antigen, Female, Melanoma
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