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Cancer Cell
Article
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Cancer Cell
Article . 2015
License: Elsevier Non-Commercial
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Cancer Cell
Article . 2015 . Peer-reviewed
License: Elsevier Non-Commercial
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Radiotherapy Complements Immune Checkpoint Blockade

Authors: Ngiow, Shin Foong; McArthur, Grant A.; Smyth, Mark J.;

Radiotherapy Complements Immune Checkpoint Blockade

Abstract

Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.

Country
Australia
Keywords

Cancer Research, T-Lymphocytes, Cell Biology, Cell Cycle Checkpoints, B7-H1 Antigen, 1307 Cell Biology, Oncology, Animals, Humans, 1306 Cancer Research, 2730 Oncology, CTLA-4 Antigen, Female, Melanoma

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    64
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
64
Top 10%
Top 10%
Top 10%
hybrid