Animal Models of Sepsis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2009 English Publisher:Elsevier BVJournal:Critical Care Clinics, volume 25, pages 703-719 (issn: 0749-0704,

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Authors: Sergio L, Zanotti-Cavazzoni; Roy D, Goldfarb;

doi: 10.1016/j.ccc.2009.08.005

pmid: 19892248

Animal Models of Sepsis

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Abstract

In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis (small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for the apparent underperformance of animal models in predicting therapeutic success of novel drugs in clinical trials.

Related Organizations

Cooper University Hospital
United States
Rutgers New Jersey Medical School
United States
University of Medicine and Dentistry of New Jersey
United States

Keywords

Disease Models, Animal, Sepsis, Drug Evaluation, Preclinical, Hemodynamics, Animals, Comorbidity, Cecum, Ligation, Shock, Septic

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