Thymidine kinase and cancer monitoring

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2012 English Publisher:Elsevier BVJournal:Cancer Letters, volume 316, pages 6-10 (issn: 0304-3835,

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Authors: Stefan, Aufderklamm; Tilman, Todenhöfer; Georgios, Gakis; Stephan, Kruck; Joerg, Hennenlotter; Arnulf, Stenzl; Christian, Schwentner;

doi: 10.1016/j.canlet.2011.10.025

pmid: 22068047

Thymidine kinase and cancer monitoring

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Abstract

Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given.

Related Organizations

University of Tübingen
Germany

Keywords

Isoenzymes, Neoplasms, Cell Cycle, Biomarkers, Tumor, Humans, Prognosis, Thymidine Kinase

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