Hypoxia-inducible factors in OSCC
Copyright policy )Hypoxia-inducible factors in OSCC
Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe HIF basic biology and tumor cells (HIF-1α, mainly), analyzing the effects of its expression in OSCC, study its relation with other molecules such as nitric oxide (NO), carbonic anhydrase (CA) or VEGF and assess the possibility of its manipulation as a therapeutic target.
Vascular Endothelial Growth Factor A, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, Cell Hypoxia, Antigens, Neoplasm, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Mouth Neoplasms, Carbonic Anhydrase IX, Hypoxia, Carbonic Anhydrases
Vascular Endothelial Growth Factor A, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, Cell Hypoxia, Antigens, Neoplasm, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Mouth Neoplasms, Carbonic Anhydrase IX, Hypoxia, Carbonic Anhydrases
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