Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling
Copyright policy )Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling
Bone marrow metastasis is frequently observed in patients with high-risk neuroblastoma. Mesenchymal stromal cells (MSCs) in bone marrow may enhance tumor metastasis through secreting stromal cell-derived factor-1 (SDF-1). Here we investigated neuroblastoma cell behaviors under the influence of MSCs and explored the function of SDF-1 signaling during metastasis. Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7. shRNA knockdown showed that these receptors were responsible for the migration of neuroblastoma towards MSCs. CXCR4 also supported neuroblastoma invasion. These effects could be effectively blocked by AMD3100, a potent SDF-1 antagonist. Our study suggests that MSCs are important for neuroblastoma metastasis via the secretion of SDF-1 and that such effect can be inhibited by AMD3100 or shRNA knockdown.
- University of Hong Kong China (People's Republic of)
- Li Ka Shing Faculty of Medicine, University of Hong Kong Hong Kong
- University of Hong Kong (香港大學) China (People's Republic of)
CXCR4, Male, Receptors, CXCR, Receptors, CXCR4, Chemotaxis, MSCs, Mesenchymal Stem Cells, CXCR7, Chemokine CXCL12, SDF-1, Neuroblastoma, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, 616, Cell Adhesion, Humans, Female, Neoplasm Metastasis, RNA, Small Interfering, Signal Transduction
CXCR4, Male, Receptors, CXCR, Receptors, CXCR4, Chemotaxis, MSCs, Mesenchymal Stem Cells, CXCR7, Chemokine CXCL12, SDF-1, Neuroblastoma, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, 616, Cell Adhesion, Humans, Female, Neoplasm Metastasis, RNA, Small Interfering, Signal Transduction
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