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Targeting the neural cell adhesion molecule in cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2007 English Publisher:Elsevier BVJournal:Cancer Letters, volume 258, pages 9-21 (issn: 0304-3835,

Authors: Markus Jensen; Frank Berthold;

doi: 10.1016/j.canlet.2007.09.004

pmid: 17949897

Targeting the neural cell adhesion molecule in cancer

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Abstract

NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations.

Related Organizations

University of Cologne
Germany

Keywords

Neoplasms, Animals, Antibodies, Monoclonal, Humans, Neural Cell Adhesion Molecules

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	80
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%