Cyclin D1 and breast cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2006 English Publisher:Elsevier BVJournal:The Breast, volume 15, pages 718-727 (issn: 0960-9776,

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Authors: Pankaj G, Roy; Alastair M, Thompson;

doi: 10.1016/j.breast.2006.02.005

pmid: 16675218

Cyclin D1 and breast cancer

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Abstract

Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues. It concludes by presenting the clinical, prognostic and therapeutic implications of our current knowledge of cyclin D1 in breast cancer.

Related Organizations

Ninewells Hospital
United Kingdom
NHS Tayside
United Kingdom

Keywords

Cyclin D, Cyclins, Cell Cycle, Humans, Breast Neoplasms, Estrogens, Female, Mammary Glands, Human

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