Ebselen effects on MPTP-induced neurotoxicity
Copyright policy )Ebselen effects on MPTP-induced neurotoxicity
We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 microM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
- University of South Dakota United States
- Auburn University System United States
- Auburn University United States
Azoles, Neurons, Glutathione Peroxidase, Dose-Response Relationship, Drug, Dopamine, Brain, Isoindoles, Antioxidants, Mice, Inbred C57BL, Disease Models, Animal, Mice, Oxidative Stress, Neuroprotective Agents, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Cell Line, Tumor, Organoselenium Compounds, Animals, Humans, Monoamine Oxidase, Cell Proliferation
Azoles, Neurons, Glutathione Peroxidase, Dose-Response Relationship, Drug, Dopamine, Brain, Isoindoles, Antioxidants, Mice, Inbred C57BL, Disease Models, Animal, Mice, Oxidative Stress, Neuroprotective Agents, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Cell Line, Tumor, Organoselenium Compounds, Animals, Humans, Monoamine Oxidase, Cell Proliferation
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