Modulation of neuronal activity by EGCG
Copyright policy )Modulation of neuronal activity by EGCG
This study aims to investigate whether (-)-epigallocatechin-3-gallate (EGCG) affects neuronal activity of acutely isolated rat medial vestibular nuclear neurons in whole-cell configuration patch-clamp experiments. EGCG (0.5 and 1 muM) lowered the spontaneous firing rate and hyperpolarized the membrane potential of medial vestibular nuclear neurons. However, it did not change the amplitude of afterhyperpolarization or the spike width of the action potential. A second application of EGCG with the same concentration elicited lesser responses. These results suggest that EGCG decreases neuronal activity by affecting potassium currents which are responsible for membrane potentials.
- Chonnam National University Korea (Republic of)
- Wonkwang University Korea (Republic of)
Neurons, Rats, Sprague-Dawley, Neuroprotective Agents, Organ Culture Techniques, Patch-Clamp Techniques, Action Potentials, Animals, Vestibular Nuclei, Catechin, Rats
Neurons, Rats, Sprague-Dawley, Neuroprotective Agents, Organ Culture Techniques, Patch-Clamp Techniques, Action Potentials, Animals, Vestibular Nuclei, Catechin, Rats
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